Alveron Pharma is based in the Netherlands and UK and is backed by venture capital managers Thuja Capital (thujacapital.com) , Waterman Ventures (watermanventures.nl), Oost NL (oostnl.nl), Zwiers Pharma BV and Sanquin Innovatie BV. The company has also received an IK loan from the Dutch government.
The drug OKL-1111 originates from a joint research project between OKKLO BV and Sanquin, the Dutch blood foundation. Alveron acquired the rights to OKL-1111 and is led by an experienced management team.
Chief Executive Officer
Ben has over 30 years’ experience in the biotechnology industry in a variety of senior commercial and managerial roles. He has managed three companies and has achieved two exits for venture capital share-holders. He was CEO of Haemostatix Ltd in the UK for ten years and led the sale to Ergomed plc in 2016. Haemostatix invented a novel class of peptide-based surgical coagulant, and developed the lead product, PeproStat, to a successful Phase II trial in 169 surgical patients with intra-operative bleeding. Their pipeline product HXP12 ReadyFlow won the Royal Society of Chemistry’s Emerging Technology competition in 2015. Ben is also Chairman of Selentus Science Ltd, a company developing an adhesive technology, TenaTac® for the application of haemostats to surgical wounds. Ben is also CEO & Chairman of Selentus. Selentus’ lead product TenaTac® is a resorbable, adhesive, surgical haemostat that reduces the risk of dislodgement and post-operative bleeding. TenaTac is approved as a Class III medical device and is being commercialised in Europe by CuraMedrix BV, a Dutch company.
Chief Operating Officer
Alex has over 20 years of experience in pharmaceutical industry, mainly regulatory affairs, and responsible for over 100 registration files. His scientific and regulatory interests have enabled him to build up a large network in the pharmaceutical industry, the regulatory framework and scientific world. He was involved in the development of Sugammadex from the early research phase to marketing authorisation approvals in Europe and several other countries. He was also led the teams responsible for the interaction strategy and management of impurities of Sugammadex. Alex is also the founder and CEO of Zwiers Regulatory Consultancy, providing pharma companies with quality regulatory support, throughout the entire drug lifecycle. His company has been responsible for bringing several products to the market which have an impact on coagulation or coagulation diseases (hemophilia).
Chief Scientific Officer
Stephan has about 20 years pharmacological R&D experience. Previously he was assistant professor and Principle Investigator Pharmacology at the Academic Medical Center in Amsterdam, working on the pharmacology and pathophysiology of sphingolipids. He was involved in biochemical pharmacology and translational research in a variety of therapeutic areas (cardiovascular, CNS, metabolic and urology). He has published more than 60 scientific papers in peer reviewed scientific journals. From 2014-2019 he was professor of Life Sciences at Fontys University of Applied Sciences, Eindhoven The Netherlands.
In the past eight years Stephan was involved in drug development within biotech industry. He is currently also Chief Scientific Officer at Okklo Life Sciences and Director Business Development at Brightlands Maastricht Health Campus (Maastricht University, the Netherlands).
Chief Technical Officer
Hash was previously Director of Technical Development at Mundipharma and was responsible for leading the Chemistry, Manufacturing and Controls (CMC) of global assets. He has expertise covering the full development of Drug Substance, for both complex protein and small molecules, and their Drug Products including, parenteral administration, oral-solid and medical devices for inhalation. Hash has many years of experience in the strategic and operational management of global contract development and manufacturing organisations (CDMOs) and has successfully advanced assets from discovery to First-in-Human studies and then from clinical research to commercialisation. Earlier in his career, he held senior programme management positions at CDMOs including Lonza Biologics and later served with several small biotechs, culminating in a partnership at Pulmagen Therapeutics LLP.
Edwin has over 25 years of experience in industrial (and academic) R&D. Previously, Edwin held positions with increasing responsibility at former Organon (now MSD, the Netherlands), the Dutch Poisons Control Center, Actelion Pharmaceuticals in Switzerland and Kinesis-Pharma in the Netherlands providing over 20 years of leadership in delivering early clinical development projects. Under his accountability he advanced over 50 compounds successfully into the clinic and through Proof of Concept phase. Recent positions include a.o. CMO/CDO for Khondrion BV, Program leader for Oncurious, and AM-Pharma.Edwin holds a PharmD since ’97 (Utrecht University) and holds registrations as a Clinical Pharmacologist (2003) and as a specialist in Pharmaceutical Medicine (2011). He is an invited lecturer in Drug Development at Utrecht University and Erasmus University Rotterdam and several commercial drug development courses. Next to his position, Edwin is involved in pediatric drug development in public-private partnerships.
Michel Briejer is a managing partner at Thuja Capital which he joined early 2008. Prior to that, he held senior management positions both in the international pharmaceutical industry (e.g. Janssen Pharmaceutica (Belgium), Yamanouchi (currently Astellas Pharma)) as well as in the biotech industry (Crucell). Michel holds an MSc degree in Pharmacy (Utrecht University) and a PhD in Pharmacology (Wageningen University), as well as a post-doctoral degree in Pharmaceutical Medicine (Dip.Phar.Med., European Center for Pharmaceutical Sciences, Basle).
Samuel Gerssen is a Managing Director at Waterman Ventures, a technology investment fund. Prior to Waterman Ventures, Samuel worked for 10 years at McKinsey & Company in Amsterdam, where he focused on Private Equity, Telecom and Financial Services.
Samuel holds a MSc. with distinction in Applied Computer Sciences from Delft University of Technology. He also holds an MBA from INSEAD.
Pieter de Geus
Pieter de Geus is Managing Director of Sanquin Health Solutions, and Sanquinnovate in Amsterdam, both entities part of the Sanquin Group.
Sanquinnovate was founded at the end of 2017 and is Sanquin’s valorization arm, focused at value creation out of scientific knowledge.
Prior to that he held senior management positions during 30 years in (Bio)Manufacturing, R&D, Change Management, Corporate Strategy and M&A at various companies such as Unilever, Gist-Brocades, royal DSM, Patheon and Sanquin. He has a track record of turning companies around in the pharma/biotech sector and positioning them for strategic growth. Pieter holds a PhD in molecular biology & biochemistry from the university of Utrecht.
Scientific Advisory Board
University of Amsterdam/Sanquin The Netherlands
Joost Meijers is Professor of Experimental Vascular Medicine in Sanquin and the Amsterdam University Medical Centers, University of Amsterdam, the Netherlands. Meijers studied Chemistry at the University of Utrecht and received his PhD degree from the Faculty of Medicine of the same university. His training included a postdoctoral research fellowship at the University of Washington in Seattle (1988-1991). Meijers is a former Fellow of the Royal Dutch Academy of Arts and Sciences (1992-1997) and Established Investigator of the Netherlands Heart Foundation (1997-2002). He was chairman of the Department of Experimental Vascular Medicine at the Academic Medical Center (1999-2014) and the Department of Plasma Proteins at Sanquin (2015-2018). He is (co-)inventor of 7 patents, including “Cyclodextrins as procoagulants”, which formed the rationale for the foundation of Alveron Pharma. His research focuses on the initiation and regulation of the coagulation and fibrinolytic systems. He published more than 390 articles on this topic.
Hugo ten Cate
Maastricht University, Maastricht, The Netherlands
Hugo ten Cate graduated in medicine at the University of Amsterdam (1987). PhD thesis on “Clinical and experimental studies with a low molecular weight heparinoid”, University of Amsterdam (1987). Postdoctoral training at the laboratory of prof Robert D Rosenberg and dr. Kenneth A Bauer, Beth Israel Hospital and Harvard Medical School Boston on mechanisms of inflammation associated coagulation activity (1988-1990). Training internal medicine completed 1996, general internist Slotervaarthospital in conjunction with research at Academic Medical Center (laboratory of Experimental Internal medicine, prof Pieter Reitsma). Clinical Established investigatorship from the Dutch Heart Foundation 1998. 2002- present: Professor in Internal medicine, Clinical Thrombosis and Haemostasis, Maastricht University Medical Center (MUMC), Maastricht. 2017- Adjunct-professor, Center for Thrombosis and Haemostasis (CTH), Gutenberg University Medical Center, Mainz, Germany.
University of Aberdeen, Aberdeen, United Kingdom
Dr. Nicola Mutch received a BSc Hons in Molecular Biology from the University of Aberdeen, UK. Her Ph.D. was carried out within the laboratory of Prof Nuala Booth at the University of Aberdeen studying cross-talk between the fibrinolytic and coagulation systems. After obtaining her Ph.D. she took up a post-doctoral position with Prof Jim Morrissey at the University of Illinois at Urbana-Champaign, Illinois, USA. During this time the laboratory uncovered the role of platelet polyphosphate in regulation of coagulation and fibrinolysis. Nicola returned to the UK to take up a tenure track position as an Independent Fellowship in Cardiovascular Biology at the University of Leeds.
She was awarded a personal Intermediate Fellowship from the British Heart Foundation and moved back to Aberdeen to pursue her research. Her research takes a global approach to study the cross-talk between hemostatic systems, with the goal of understanding the normal biological processes that regulate these complex pathways and perturbations during disease.
Mc Master University, Hamilton, Canada
Dr. Weitz is Professor of Medicine and Biochemistry and Biomedical Sciences at McMaster University and Executive Director of the Thrombosis and Atherosclerosis Research Institute. Board Certified in Internal Medicine, Hematology and Medical Oncology, Dr. Weitz focuses his clinical practice on patients with thrombotic disorders. His research spans the spectrum from basic studies in the biochemistry of blood coagulation and fibrinolysis to animal models of thrombosis and on to clinical trials of antithrombotic therapy. The breadth of his work is highlighted by his over 530 publications in journals as diverse as the Journal of Clinical Investigation, Journal of Biological Chemistry, Biochemistry, Circulation, Blood, Annals of Internal Medicine, New England Journal of Medicine and Lancet, and 65 book chapters. The recipient of numerous awards, Dr. Weitz is a Fellow of the American Heart Association, the Royal Society of Canada and the Canadian Academy of Health Sciences.
Radboud University Medical Center, Nijmegen, The Netherlands
Saskia Middeldorp is Professor of Medicine and Head of the Department of Internal Medicine of the Radboud University Medical Center in Nijmegen, The Netherlands. Prior to her transfer to Nijmegen in January 2021, she has been a professor of Medicine at Amsterdam University Medical Centers for over 10 years, leading the clinical thrombosis and haemostasis research lines of the Department of Vascular Medicine.
Her present research focuses on several aspects of hereditary and acquired thrombophilia, women’s issues in thrombosis and haemostasis, and the clinical evaluation of new anticoagulants and antidotes. She is principal investigator of practice-changing trials such as the investigator-initiated ALIFE, ALIFE2 and Highlow randomized controlled trials.
Saskia Middeldorp is elected council member of the International Society of Thrombosis and Haemostasis, immediate past chair of the INVENT-VTE network, Associate Editor of the Journal of Thrombosis and Haemostasis and Editorial Board Member of Blood.
She is chair of the Thrombophilia Chapter of ASH VTE Guidelines (expected 2023). Saskia Middeldorp has co-authored the Pregnancy chapter of the ASH pregnancy guideline in 2018 as well as the 9th Edition Antithrombotic Guidelines of the American College of Chest Physicians (ACCP) in 2012.
Saskia has supervised and still supervises numerous PhD students and has co-authored over 400 peer-reviewed papers and several book chapters, and reviews manuscripts for international scientific journals.
University of Manchester, Manchester, United Kingdom
Adrian Parry-Jones is Margaret Giffen Stroke Association Reader at the University of Manchester and an Honorary Consultant Neurologist at the Northern Care Alliance NHS Foundation Trust in Manchester in the UK. Prior to his current role, he held an NIHR Clinician Scientist Award at the University of Manchester from 2015-2020 and was the Clinical Director of the Greater Manchester Integrated Stroke Delivery Network (2021-22). His research and clinical work are focused on improving outcomes after intracerebral haemorrhage, a devastating form of stroke with poor outcomes and few treatments. He pioneered the use of a care-bundle approach to treating intracerebral haemorrhage and is leading work to implement this across the North of England. He was the ICH topic group chair for the 2023 update of the UK National Stroke Guideline and his research includes early phase clinical studies and trials to target the inflammatory response to intracerebral haemorrhage as part of a large multidisciplinary translational research group in Manchester.
Thuja Capital (“Thuja”) manages several venture capital funds aimed at building and scaling companies in the fields of (bio)pharmaceuticals, medtech and digital health. Thuja brings innovation to patients and society by providing capital to daring entrepreneurs with ground-breaking product concepts, addressing unmet medical needs. The investment team at Thuja consists of seasoned investors and entrepreneurs with a proven track record and an extensive network.
Waterman Ventures invests in ambitious technology companies that combine a positive impact on society with a healthy financial return. Over the last 30 years, we have been a long-term partner to many successful businesses. Our team, based in the Netherlands, shares a passion for technology and a hands-on mindset to supporting growth in our portfolio companies.
Oost NL (East Netherlands Development Agency) is an agency that focuses its activities and projects on strengthening and stimulating the economy of the provinces of Gelderland and Overijssel, the Netherlands. Oost NL supports starting and growth-phase SMEs. We do this partly with risk capital from various revolving innovation funds, and partly through our knowledge, networks and personal contacts. Through the revolving funds we provide for direct as well as indirect investment and take care of the fund management. In addition, we stimulate and support public and private investors.