News & Media
May 16, 2019
Alveron Pharma closes series A round to advance a cyclodextrin based procoagulant medicine into the clinic. 

16th May 2019, Nijmegen, The Netherlands

Alveron Pharma, a newly incorporated company established by Okklo Life Sciences BV and

Sanquinnovate (part of Sanquin), is pleased to announce the closing of a EUR 6.5M Series A financing round led by Thuja together with Waterman Ventures and Oost NL. This investment allows Alveron Pharma to select a lead compound, conduct non-clinical studies, and complete a first clinical study to demonstrate safety and obtain a first clinical readout.

Alveron Pharma will focus on a unique class of cyclodextrin-based drugs, that have the ability to promote blood coagulation without inducing it in the absence of bleeding. Alveron’s first target is to reverse the effects of anticoagulants. Anticoagulants (“blood thinners”) are widely prescribed to patients with increased thromboembolic risk. While effective in preventing thrombosis, these drugs also inhibit blood coagulation when this is needed urgently, e.g. in patients who suffer a major bleed or in case of emergency surgery. Anticoagulant related bleedings are not uncommon, and may be serious, and difficult to treat since no or only selective reversal agents are available. Alveron’s cyclodextrins are unique in the sense that they restore coagulation independent of the type of anticoagulant used. Sales of selective reversal agents have been estimated at around $2 billion per annum.

Ben Nichols, CEO of Alveron Pharma: “There is a clear unmet clinical need for a universal anticoagulant reversal agent, and the early pre-clinical data for Alveron’s unique cyclodextrin compounds are compelling. Having recently taken a new class of coagulant into clinical trials, I am thrilled to be joining the founders of this business, Stephan Peters (who conceived the original idea, CSO) and Alex Zwiers (COO), with their expertise on cyclodextrins, and coagulation expert at Sanquin, Joost Meijers (Chairman of the Scientific Advisory Board). Alex was also involved in the development of the world’s first cyclodextrin-based medicine, Bridion®.”

“Multiple factors come together in this investment that are highly attractive”, says Michel

Briejer of Thuja, who led this transaction. “A highly experienced and knowledgeable team, a promising set of drug leads, and a reputable partner in the field of blood, Sanquin. We are extremely pleased to be part of this venture and are confident that Alveron will create success for doctors and patients alike.”

Thuja Capital (“Thuja”) manages several venture capital

funds aimed at building and scaling companies in the fields

of (bio)pharmaceuticals, medtech and digital health. Thuja

brings innovation to patients and society by providing capital to daring entrepreneurs with

ground-breaking product concepts, addressing unmet medicaln eeds.


Waterman Ventures invests in ambitious technology companies that combine a positive impact on society with a healthy financial return.Over the last 30 years, we have been a long-term partner to many successful businesses. Our team, based in the Netherlands, shares a passion for technology and a hands-on mindset to supporting growth in our portfolio companies.


Oost NL (East Netherlands Development Agency) is an

agency that focuses its activities and projects on strengthening and stimulating the economy of the provinces of Gelderland and Overijssel, the Netherlands.

Oost NL supports starting and growth-phase SMEs. We do this partly with risk capital from

various revolving innovation funds, and partly through our knowledge, networks and personal contacts.

Press release Alveron - FOR RELEASE 16th

Sanquinnovate (Sanquin Innovatie BV) is Sanquin’s valorization

branch focused on creating new value-adding products and

services to tackle challenges in blood-related disease fields

through partnering, spin-offs and top-notch research

collaborations. Sanquin is an internationally highly respected research institute in the field of blood, transfusion, medicine and immunology, applying this knowledge to the development and manufacturing of a range of pharmaceutical and diagnostic products and services.

Okklo Life Sciences B.V. is a privately held 

biopharmaceutical company developing novel therapeutic solutions using cyclodextrin-based technologies. The company was founded by a team of life sciences experts

previously involved in the development and approval of sugammadex (Bridion®), the first modified cyclodextrin (CD) marketed as a drug product.